Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent

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A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC.

The extra sex combs (ESC) and Enhancer of zeste [E(Z)] proteins, members of the Polycomb group (PcG) of transcriptional repressors, interact directly and are coassociated in fly embryos. We report that these two proteins are components of a 600-kDa complex in embryos. Using gel filtration and affinity chromatography, we show that this complex is biochemically distinct from previously described ...

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ژورنال

عنوان ژورنال: Developmental Biology

سال: 2008

ISSN: 0012-1606

DOI: 10.1016/j.ydbio.2007.10.025